• slide1

    A protein–protein interaction domain (PPID) (PDB ID: 1YCR)

  • slide2

    A PPID-fragment (short linear peptide) (PDB ID: 1YCR)

  • slide3

    PPI function of a PPID prevented specifically (PDB ID: 1YCR)

Peptide PPI inhibitors

peptide ppi inhibitor fig tool


A short linear peptide that matches (a part of) a specific protein–protein interaction domain (PPID) can be used as a tool that binds to a corresponding interacting / complementary PPID of an endogenous protein when added to cells in culture. As a consequence of that binding, PPI function of the targeted PPID will be prevented specifically—loss of PPI function can disrupt a cellular process.


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