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  • slide2_PPID-fragment_short_linear_peptide_PDB_ID_1YCR.png
  • slide3_PPI_function_of_a_PPID_prevented_specifically_PDB_ID_1YCR.png

Peptide PPI inhibitors

peptide ppi inhibitor fig tool

 

A short linear peptide that matches (a part of) a specific protein–protein interaction domain (PPID) can be used as a tool that binds to a corresponding interacting/complementary PPID of an endogenous protein when added to cells in culture. As a consequence of that binding, PPI function of the targeted PPID will be prevented specifically—loss of PPI function can disrupt a cellular process.

 

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